Deoxyhaemoglobin S

Haemoglobin Molecular Structure

open educational resources – genetics

Content Author:

Dr Mark Fowler

Level:

Undergraduate bioscience

OER Features (6 components):

Deoxyhaemoglobin PDF (Molecular structure of deoxyhaemoglobin A PDF)

Deoxyhaemoglobin PPT (Powerpoint slides with notes)

Deoxyhaemoglobin S PDF (Sickle cell form of haemoglobin PDF)

Deoxyhaemoglobin S PPT (Powerpoint slides with notes)

Deoxyhaemoglobin A

Deoxyhaemoglobin S

OER Description:

Jmol (http://jmol.sourceforge.net) is an open-source Java viewer that is excellent for creating 3D chemical structures. In this OER, Dr Mark Fowler has used the Jmol software to produce structures of deoxyhaemoglobin A, that is, normal adult haemoglobin, and also deoxyhaemoglobin S that features in sickle cell disease. The subtle genetic mutation causes quite dramatic changes to the molecular structure, and this in turn alters the oxygen-binding capability of the molecule.

This is an open educational resource part of the ‘SCOOTER Project’ funded in the UK by the Jisc/HEA Open Educational Resource Programme. We aim to support the teaching of sickle cell and raise awareness of the condition.

Further Resources:

You may wish to refer back to some of our genetic materials to look at the heredity aspects and how the haemoglobin gene becomes mutated.

http://www.sicklecellanaemia.org/category/open-education-resources/genetics

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IMG_0258

Detecting Genetic Mutations

open educational resources – genetics

Content Author:

Dr Mark Fowler

Level:

Undergraduate bioscience

OER Features (6 components):

Lab technique ASO (PDF file of lecture slides)
Lab technique ASO (Powerpoint file – slides plus lecture notes)

Lab technique ARMS (PDF file of lecture slides)
Lab technique ARMS PPT (Powerpoint file – slides plus lecture notes)

Lab technique RFLP PDF (PDF file of lecture slides)
Lab technique RFLP PPT (Powerpoint file – slides plus lecture notes)

OER Description:

A series of slides (in PDF format or as Powerpoint files with slides and notes). These OERs describe a number of laboratory techniques used to detect genetic mutations, and in these cases, are used in the study of sickle cell disease and haemoglobin disorders.

This is an open educational resource part of the ‘SCOOTER Project’ funded in the UK by the Jisc/HEA Open Educational Resource Programme. We aim to support the teaching of sickle cell and raise awareness of the condition.

Further Resources:

The Virtual Genetics Education Centre, University of Leicester.

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Detecting Sickle Cell Mutations by the ASO Technique

open educational resources – genetics

Content Author:

Dr Mark Fowler

Level:

Undergraduate bioscience

OER Features (3 components):

Video MP4 describing patterns of inheritance for haemoglobin disorders

Lab technique ASO (PDF file of lecture slides)
Lab technique ASO (Powerpoint file – slides plus lecture notes)

OER Description:

A video resource describing a common laboratory technique for detecting genetic mutations, and in our example we look at sickle cell disease. ASO stands for ‘allele-specific oligonucleotide’ hybridisation. Simply, a short piece of DNA is synthesised to act like a probe that can then detect certain mutations in patient samples.

This is an open educational resource part of the ‘SCOOTER Project’ funded in the UK by the Jisc/HEA Open Educational Resource Programme. We aim to support the teaching of sickle cell and raise awareness of the condition.

Further Resources:

The Virtual Genetics Education Centre, University of Leicester.

 

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