Category Archives: Haematology

Deoxyhaemoglobin S

Haemoglobin Molecular Structure

open educational resources – genetics

Content Author:

Dr Mark Fowler

Level:

Undergraduate bioscience

OER Features (6 components):

Deoxyhaemoglobin PDF (Molecular structure of deoxyhaemoglobin A PDF)

Deoxyhaemoglobin PPT (Powerpoint slides with notes)

Deoxyhaemoglobin S PDF (Sickle cell form of haemoglobin PDF)

Deoxyhaemoglobin S PPT (Powerpoint slides with notes)

Deoxyhaemoglobin A

Deoxyhaemoglobin S

OER Description:

Jmol (http://jmol.sourceforge.net) is an open-source Java viewer that is excellent for creating 3D chemical structures. In this OER, Dr Mark Fowler has used the Jmol software to produce structures of deoxyhaemoglobin A, that is, normal adult haemoglobin, and also deoxyhaemoglobin S that features in sickle cell disease. The subtle genetic mutation causes quite dramatic changes to the molecular structure, and this in turn alters the oxygen-binding capability of the molecule.

This is an open educational resource part of the ‘SCOOTER Project’ funded in the UK by the Jisc/HEA Open Educational Resource Programme. We aim to support the teaching of sickle cell and raise awareness of the condition.

Further Resources:

You may wish to refer back to some of our genetic materials to look at the heredity aspects and how the haemoglobin gene becomes mutated.

http://www.sicklecellanaemia.org/category/open-education-resources/genetics

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Haematology case study 2 – neonatal blood


 
Image: Identification of neonatal blood smear by IEF.
Creative Commons BY SA.

Author:

Keith Chambers,   Leicester Royal Infirmary

Level:

Undergraduate or postgraduate science / medical students

OER Features a bundle of 6 resources:

Documents to download:

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER97a_Neonate_Case_study.doc

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER97b_Neonate_Case_study.pdf

Images:

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER97c_Neonate_IEF.png

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER97d_Neonate_IEF.gif

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER97e_Neonate_HPLC.png

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER97f_Neonate_HPLC.gif

 

OER Description:

These haematology open educational resources are produced by the Leicester Royal Infirmary and consist of case studies of diagnostic techniques for characterising adult human blood. The OERs include case study documents (Word.doc and .pdf); images of the isoelectric focusing (IEF) technique, which is a means of separating molecules, and images of HPLC results.

You could use the case study materials for discussion points with medical and biomedical science university students, or unpack the results and make your own resources. All the assets are licences using Creative Commons BY SA – so you are free to adapt the resources to suit your need. If you are a student, you can use these resources in your own learning, revision and work.

This case study looks at neonatal blood, that is, of the newborn infant. The blood preparation is fascinating, and compared to the adult you will see that the red blood cells are all different shapes and sizes. The body hasn’t got the production of cells down to a fine art just yet and they are produced at all different rates. The haemoglobin content dramatically varies from in utero, to birth and through to adult hood, with the prevalence of a foetal form – HbF. You will note this on some of the traces in the case study.

This is one of FOUR case studies. Here is a ZIPPED package of the entire collection (32MB).

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER 96 Sickle Cell Case Studies DOCS and IMAGES Jan2014.zip

 

OER in Case Study Series:

Case study 1 – adult blood
Case study 2 – neonate
Case study 3 – sickle cell trait
Case study 4 – sickle cell disease

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Haematology case study 4 – sickle cell disease

Image: Identification of sickle cell disease by HPLC.
Creative Commons BY SA.

Author:

Keith Chambers,   Leicester Royal Infirmary

Level:

Undergraduate or postgraduate science / medical students

 

OER Features a bundle of 6 resources:

Documents to download:

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER99a_Sickle_Cell_Disease_Case_Study.doc

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER99b_Sickle_Cell_Disease_Case_Study.pdf

 

Images:

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER99c_Sickle_Cell_Disease_IEF.png

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER99d_Sickle_Cell_Disease_IEF.gif

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER99e_Sickle_Cell_Disease_HPLC.png

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER99f_Sickle_Cell_Disease_HPLC.gif

OER Description:

These haematology open educational resources are produced by the Leicester Royal Infirmary and consist of case studies of diagnostic techniques for characterising adult human blood. The OERs include case study documents (Word.doc and .pdf); images of the isoelectric focusing (IEF) technique, which is a means of separating molecules, and images of HPLC results.

You could use the case study materials for discussion points with medical and biomedical science university students, or unpack the results and make your own resources. All the assets are licences using Creative Commons BY SA – so you are free to adapt the resources to suit your need. If you are a student, you can use these resources in your own learning, revision and work.

This case study looks at blood from a person with sickle cell disease,  that is, someone who carries both alleles for HbS and displays symptoms characteristic of the condition.  The blood preparation may contain distinctive sickle shaped cells, and a full identification would be done in conjunction with other techniques to verify the condition, such as the IEF or HPLC.

This is one of FOUR case studies. Here is a ZIPPED package of the entire collection (32MB).

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER 96 Sickle Cell Case Studies DOCS and IMAGES Jan2014.zip

 

OER in Case Study Series:

Case study 1 – adult blood
Case study 2 – neonate
Case study 3 – sickle cell trait
Case study 4 – sickle cell disease

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