Haematology case study 3 – sickle cell trait

 

Image: Identification of sickle cell trait by IEF and looking at the distribution of haemoglobin in the gel (Hb)
Creative Commons BY SA.

Author:

Keith Chambers,   Leicester Royal Infirmary

Level:

Undergraduate or postgraduate science / medical students

OER Features a bundle of 6 resources:

Documents to download:

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER98a_Sickle_Trait_Case_Study.doc

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER98b_Sickle_Trait_Case_Study.pdf

 

Images:

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER98c_Sickle_Trait_IEF.png

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER98d_Sickle_Trait_IEF.gif

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER98e_Sickle_Trait_HPLC.png

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER98f_Sickle_Trait_HPLC.gif

 

OER Description:

These haematology open educational resources are produced by the Leicester Royal Infirmary and consist of case studies of diagnostic techniques for characterising adult human blood. The OERs include case study documents (Word.doc and .pdf); images of the isoelectric focusing (IEF) technique, which is a means of separating molecules, and images of HPLC results.

You could use the case study materials for discussion points with medical and biomedical science university students, or unpack the results and make your own resources. All the assets are licences using Creative Commons BY SA – so you are free to adapt the resources to suit your need. If you are a student, you can use these resources in your own learning, revision and work.

This case study looks at blood from a person with sickle cell trait, that is, someone who carries one of the alleles for for the Hb beta gene (but is heterozygous and does not display the full symptoms). However it is important to know whether you have sickle cell trait in case you wish to have children yourself, and also because some people do display mild symptoms. The blood preparation may contain some sickle shaped cells, and a full identification would be done in conjunction with other techniques to verify it, such as the IEF or HPLC.

This is one of FOUR case studies. Here is a ZIPPED package of the entire collection (32MB).

http://www.sicklecellanaemia.org/teaching-resources/resources/scooter96/SCOOTER 96 Sickle Cell Case Studies DOCS and IMAGES Jan2014.zip

 

OER in Case Study Series:

Case study 1 – adult blood
Case study 2 – neonate
Case study 3 – sickle cell trait
Case study 4 – sickle cell disease

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